The Shared Instrument Grant (SIF) Program 2019 call for applications is closed. The previous call is below for your reference only.  An updated call for applications will be announced when/if NIH  announces a new SIG funding opportunity.  Please check the ECOR website and your emails from MGH Research News for updates. Click here to sign up to receive MGH Research News.

Shared Instrumentation Grant (SIG) Program 2021 and High-End Instrumentation Grant Program (HEI) 2021

Pre-application Deadline: Wednesday, March 31, 2021 - 5:00 PM



From the NIH call the NIH ORIP's Shared Instrumentation Grant (S10) program, also known as a SIG, supports the purchase or upgrade of a single item of high-priced, specialized, commercially available instruments or integrated systems in the $50,000 to $600,000 price range. Examples of instrumentation supported by SIG funding include, but are not limited to: X-ray diffractometers, mass spectrometers, nuclear magnetic resonance spectrometers, DNA and protein sequencers, biosensors, electron and light microscopes, cell sorters, and biomedical imagers. For research equipment exceeding the $600,000 price range, investigators may apply for the High-End Instrumentation (HEI) Grant Program. Please note that the maximum award is $2,000,000 of direct costs for an HEI grant.

The MGH Executive Committee on Research (ECOR) has again committed funding to provide institutional support this year for Shared Instrumentation Grant (S10) and High-End Instrumentation (HEI) Grant proposals. ECOR has made this commitment because it recognizes that institutional support greatly increases the likelihood that a S10 or HEI application will be funded.


Since 2014, the following has been required in each SIG/HEI application:

  • The institution must explicitly state a commitment to provide financial support for the proposed financial plan should a shortfall be experienced due to a lack of other grant funding or chargeback/volume fluctuations (see Sect. IV).
    • A separate communication will be sent directly to department chiefs addressing the support of financial plans for submitted applications.
  • The institution must also provide a Letter of Support that includes a table that provides information about instrument performance of all previous S10 awards for instruments awarded or installed within the past five years.
    • To meet this requirement, any recipient of an S10 award from 2016-present will be asked to provide specific details that will be used to support all shared instrumentation grants going forward. A separate email will be sent directly to the PIs to which this applies.

The Pre-application must be submitted through MGH ECOR's Online Grant Management Portal by the MGH PI or their delegate.



The internal review process is meant to help strengthen each NIH application, confirm space requirements, and to determine the level of institutional support.

We understand that the NIH application is extensive and that the process takes a lot of preparation. For this reason, please continue working on your NIH application while ECOR reviews your internal application. In addition, the reviewers may provide feedback that will help strengthen the final application. During the review process, ECOR may reach out to PIs if they have any questions.

Applicants will receive a letter of institutional support required to submit the application to NIH.    



ECOR Pre-application Deadline:  Wednesday, March 31, 2021, 5pm

NIH Application Deadline:  Tuesday, June 1, 2021



As previously stated, the Shared Instrumentation Grant (SIG) Program awards range from $50,0000 to $600,000  for the purchase or upgrade of a single item of expensive, specialized, commercially available instruments or integrated systems. The Hight-End Instrumentation (HEI) Grant Program supports the purchase or upgrade of research equipment exceeding the $600,000 price range. NIH also requires a letter confirming the institution's financial commitment and support.



  • Applicants must have a full-time MGH appointment at the time of application and during the entire award period.
  • Applicants must hold their primary appointment at MGH and their research must be based at MGH.
  • At Mass General Hospital we believe that because of diversity we excel.  Therefore, women and URM candidates are strongly encouraged to apply



The pre-application must include the following 13 items:

  1. Title of Submission
  2. Type of Grant:  Choose one of the following two categories based on the type of grant application being submitted to NIH: Shared Instrument Grant or High-End Instrumentation (HEI) Grant.
  3. Application status. Is this a new application or resubmission to NIH? If this is a resubmission, please upload the NIH comments from the previous application.
  4. Equipment Requested.
    • Include the name of the equipment and a URL for specifications. 
    • Select "Update" if the purchase will replace existing equipment.
    • Does the equipment already exist on an MGH campus?  If yes, explain why the equipment is not accessible or cannot be used. 
  5. Estimated Cost of Equipment.
  6. Planned Location of Equipment.  Include Building, Floor and Room #
  7. Renovation Required.  Will any renovations be required to install the equipment? Select Yes or No.  If yes, who will be paying for the renovations? What is the estimated cost of the renovations (If an estimate is available at time of ECOR application)?
  8. Signed Statement Confirming Renovations (Signed by Department Chief and Unit/Division Chief/Center Director). If renovations are required for your project, please download this Confirmation of Endorsement Form and review it with your Chief and Unit/Division Chief/Center Director. The costs of any renovations or enhancements of infrastructure that exceed the committed funds provided by ECOR are the financial responsibility of the department. By signing this form, the Chief or Center acknowledges that they are aware of this arrangement and will be responsible for any additional costs for the renovation or enhancement.
  9. Significance. What is the significance of procuring this piece of equipment to your research lab, department and the institution?  Please be specific in discussing your field of study and the impact of this equipment.
  10. Use of Institutional Funds.  What do you plan to do with the institutional funds? (i.e. procurement, maintenance, etc. )
  11. Potential Users (If available at time of ECOR application). List a minimum of 3 Major Users. Include name, degree(s), department and institution.
    • Major Users must be a PD/PI on a distinct active NIH research award in an area of basic, translational or clinical research.  An award given to multi PDs/PIs is counted only once. NIH training or fellowship grants and other non-research grants cannot be counted. 
    • Investigators with funding from sources such as other federal agencies (e.g., NSF, DoD), private foundations or academic institutions can be listed as Major Users, provided they are engaged in basic, translational or clinical research and can demonstrate a substantial need for the instrument.
    • Major Users can be researchers from the same department or from several departments or divisions at MGH or from nearby or regional institutions. 
    • Major users may come from distant institutions, but they must demonstrate the need for the instruments and describe plans for regular access to the instrument
  12. Technical Expertise (250 words maximum) Per the NIH Call, the PI for this application should have documented technical expertise directly related to the type of the chosen instrument.  Describe very briefly the technical expertise of the individuals who will set up and run the instrument, ensure that the instrument is safely operated and appropriately maintained and who will train users.
  13. Administration - Organizational/Management Plan (1 page maximum): Briefly describe the organizational plan to administer the grant. Describe how requests to use the instrument will be enlisted.  Describe typical day-by-day management of the instrument.



  • Use margins of 0.5 inches or greater
  • Use 11pt font size or greater
  • Upload PDF documents only.  Limit characters to A-Z, a-z and 0-9 when naming PDF documents.  Do not use periods, commas or dashes in the file name.



ECOR accepts all applications online via the MGRI Online Grant Management Portal.  The system has been designed to allow users to:

  • Create a personal profile, which will auto-populate your future ECOR applications
  • Assign a delegate to submit applications on your behalf (optional)
  • View current calls and apply to open opportunities 
  • Save and edit current applications in progress
  • Submit completed applications
  • View all your ECOR applications that have been submitted via the Online Grants Management Portal.

Instructions for Applying Online:

  1. Create your account: Log in using your Partners credentials and fill-out the profile information.
  2. Complete the application: Once your profile is complete, you will automatically progress through the online application. If you cannot complete the application at one time, “save” the application and return to it at a later time to finish. Before submitting your application, you will have the ability to make changes to the application.
  3. Submit your application: Once you have completed the application click on the “submit” button at the bottom of the page. Once you submit it, you will not be able to make further changes unless you send a request to ECOR (note that once the deadline passes, requests to make changes will not be accepted).

Useful tips:

  • To avoid losing your work, remember to save frequently
  • You can only upload PDF documents
  • If you previously created a profile, please ensure your information is current prior to submitting an application.

  Click 'Apply' below to begin the application.



If you have any questions, please email ECOR.