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Matt T Bianchi, MD, PhD
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Assistant In Neurology, Massachusetts General Hospital
Assistant Professor, Harvard Medical School
Department: Neurology Service
Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114
PROFILE SUMMARY
PUBLICATIONS
RESEARCH NARRATIVE
GROUP MEMBERS
Education:
University of Michigan Medical School, 2004, MD, PhD
Keywords (MeSH):
Desoxycorticosterone
Ion Channels
Public Opinion
Receptors, GABA-A
Ion Channel Gating
Sleep Stages
gamma-Aminobutyric Acid
Diagnosis
Publications (Pulled from Harvard Catalyst Profiles):
1. Ferguson M, Bianchi MT, Sutter R, Rosenthal ES, Cash SS, Kaplan PW, Westover MB. Calculating the Risk Benefit Equation for Aggressive Treatment of Non-convulsive Status Epilepticus. Neurocrit Care. 2013 Apr; 18(2):216-27.
2. Westover MB, Bianchi MT, Shafi M, Hoch DB, Cole AJ, Chiappa K, Cash SS. Inferring seizure frequency from brief EEG recordings. J Clin Neurophysiol. 2013 Apr; 30(2):174-7.
3. Westover MB, Bianchi MT, Yang C, Schneider JA, Greenberg SM. Estimating cerebral microinfarct burden from autopsy samples. Neurology. 2013 Apr 9; 80(15):1365-9.
4. Eiseman NA, Westover MB, Ellenbogen JM, Bianchi MT. The impact of body posture and sleep stages on sleep apnea severity in adults. J Clin Sleep Med. 2012; 8(6):655-66.
5. Westover MB, Eiseman NA, Cash SS, Bianchi MT. Information theoretic quantification of diagnostic uncertainty. Open Med Inform J. 2012; 6:36-50.
6. Proctor A, Bianchi MT. Clinical pharmacology in sleep medicine. ISRN Pharmacol. 2012; 2012:914168.
7. Bianchi MT, Wang W, Klerman EB. Sleep misperception in healthy adults: implications for insomnia diagnosis. J Clin Sleep Med. 2012; 8(5):547-54.
8. Kelly JM, Strecker RE, Bianchi MT. Recent developments in home sleep-monitoring devices. ISRN Neurol. 2012; 2012:768794.
9. Kelly JM, Bianchi MT. Mammalian sleep genetics. Neurogenetics. 2012 Nov; 13(4):287-326.
10. Srinivasan P, Westover MB, Bianchi MT. Propagation of uncertainty in Bayesian diagnostic test interpretation. South Med J. 2012 Sep; 105(9):452-9.
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11. Bianchi MT, Thomas RJ, Ellenbogen JM. Hypnotics and mortality risk. J Clin Sleep Med. 2012; 8(4):351-2.
12. Kelly JM, Schwamm LH, Bianchi MT. Sleep telemedicine: a survey study of patient preferences. ISRN Neurol. 2012; 2012:135329.
13. Westover MB, Eiseman NA, Bianchi MT. Should risky treatments be reserved for secondary prevention? Theoretical considerations regarding risk-benefit tradeoffs. J Clin Epidemiol. 2012 Aug; 65(8):877-86.
14. Kudesia RS, Bianchi MT. Decreased nocturnal awakenings in young adults performing bikram yoga: a low-constraint home sleep monitoring study. ISRN Neurol. 2012; 2012:153745.
15. Chu CJ, Kramer MA, Pathmanathan J, Bianchi MT, Westover MB, Wizon L, Cash SS. Emergence of stable functional networks in long-term human electroencephalography. J Neurosci. 2012 Feb 22; 32(8):2703-13.
16. Westover MB, Cormier J, Bianchi MT, Shafi M, Kilbride R, Cole AJ, Cash SS. Revising the "Rule of Three" for inferring seizure freedom. Epilepsia. 2012 Feb; 53(2):368-76.
17. Kramer MA, Eden UT, Lepage KQ, Kolaczyk ED, Bianchi MT, Cash SS. Emergence of persistent networks in long-term intracranial EEG recordings. J Neurosci. 2011 Nov 2; 31(44):15757-67.
18. Bianchi MT, Eiseman NA, Cash SS, Mietus J, Peng CK, Thomas RJ. Probabilistic sleep architecture models in patients with and without sleep apnea. J Sleep Res. 2012 Jun; 21(3):330-41.
19. Cochrane T, Bianchi MT. "Take my organs, please": a section of my living will. Am J Bioeth. 2011 Aug; 11(8):56-8.
20. Eiseman NA, Westover MB, Mietus JE, Thomas RJ, Bianchi MT. Classification algorithms for predicting sleepiness and sleep apnea severity. J Sleep Res. 2012 Feb; 21(1):101-12.
21. Bianchi MT, Clark AG, Fisher JL. The wake-promoting transmitter histamine preferentially enhances a-4 subunit-containing GABAA receptors. Neuropharmacology. 2011 Sep; 61(4):747-52.
22. Westover MB, Westover KD, Bianchi MT. Significance testing as perverse probabilistic reasoning. BMC Med. 2011; 9:20.
23. Chu-Shore CJ, Kramer MA, Bianchi MT, Caviness VS, Cash SS. Network analysis: applications for the developing brain. J Child Neurol. 2011 Apr; 26(4):488-500.
24. Westover MB, Bianchi MT, Eckman MH, Greenberg SM. Statin use following intracerebral hemorrhage: a decision analysis. Arch Neurol. 2011 May; 68(5):573-9.
25. Citi L, Bianchi MT, Klerman EB, Barbieri R. Instantaneous monitoring of sleep fragmentation by point process heart rate variability and respiratory dynamics. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:7735-8.
26. Chu-Shore J, Westover MB, Bianchi MT. Power law versus exponential state transition dynamics: application to sleep-wake architecture. PLoS One. 2010; 5(12):e14204.
27. Nakagawa K, Bianchi MT, Nakagawa SS, Sorond FA. Aggressive care after a massive stroke in young patients: is that what they want? Neurocrit Care. 2010 Aug; 13(1):118-22.
28. Bianchi MT, Cash SS, Mietus J, Peng CK, Thomas R. Obstructive sleep apnea alters sleep stage transition dynamics. PLoS One. 2010; 5(6):e11356.
29. Bianchi MT, Botzolakis EJ. Targeting ligand-gated ion channels in neurology and psychiatry: is pharmacological promiscuity an obstacle or an opportunity? BMC Pharmacol. 2010; 10:3.
30. Bianchi MT. Context dependent benzodiazepine modulation of GABA(A) receptor opening frequency. Curr Neuropharmacol. 2010 Mar; 8(1):10-7.
31. Cohen AB, Bianchi MT. Commentary: Neurological perspective. BMJ. 2009; 339:b5250.
32. Bianchi MT. Promiscuous modulation of ion channels by anti-psychotic and anti-dementia medications. Med Hypotheses. 2010 Feb; 74(2):297-300.
33. Bianchi MT, Westover B. Analysis of SPARCL trial data for reduction of future stroke risk in older stroke patients with recent stroke or TIA. Neurology. 2009 Sep 8; 73(10):817-8; author reply 818.
34. Bianchi MT, Lavigne C, Sorond F, Bermas B. Transient life-threatening cerebral edema in a patient with systemic lupus erythematosus. J Clin Rheumatol. 2009 Jun; 15(4):181-4.
35. Bianchi MT, Botzolakis EJ, Lagrange AH, Macdonald RL. Benzodiazepine modulation of GABA(A) receptor opening frequency depends on activation context: a patch clamp and simulation study. Epilepsy Res. 2009 Aug; 85(2-3):212-20.
36. Bianchi, M.T. Screening for Obstructive Sleep Apnea: Bayes Weighs In. The Open Sleep Journal. 2009; 2:56-59.
37. Bianchi MT, Pathmanathan J, Cash SS. From ion channels to complex networks: magic bullet versus magic shotgun approaches to anticonvulsant pharmacotherapy. Med Hypotheses. 2009 Mar; 72(3):297-305.
38. Bianchi MT, Alexander BM, Cash SS. Incorporating uncertainty into medical decision making: an approach to unexpected test results. Med Decis Making. 2009 Jan-Feb; 29(1):116-24.
39. Bianchi MT, Dworetzky BA, Bromfield EB. Auditory auras in patients with postencephalitic epilepsy: case series. Epilepsy Behav. 2009 Jan; 14(1):250-2.
40. Bianchi MT. Desiderata or dogma: what the evidence reveals about physician attire. J Gen Intern Med. 2008 May; 23(5):641-3.
41. Bianchi MT, Sims JR. Restricted diffusion in the splenium of the corpus callosum after cardiac arrest. Open Neuroimag J. 2008; 2:1-4.
42. Bianchi MT. Non-serotonin anti-depressant actions: direct ion channel modulation by SSRIs and the concept of single agent poly-pharmacy. Med Hypotheses. 2008; 70(5):951-6.
43. Bianchi MT, Botzolakis EJ, Haas KF, Fisher JL, Macdonald RL. Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation. J Physiol. 2007 Nov 1; 584(Pt 3):769-87.
44. Bianchi, M.T. The pharmacology of insomnia: targeting GABAA receptor function. International J Sleep and Wakefulness . 2007; 1(3).
45. Bianchi MT, Alexander BM. Evidence based diagnosis: does the language reflect the theory? BMJ. 2006 Aug 26; 333(7565):442-5.
46. Feng HJ, Bianchi MT, Macdonald RL. Pentobarbital differentially modulates alpha1beta3delta and alpha1beta3gamma2L GABAA receptor currents. Mol Pharmacol. 2004 Oct; 66(4):988-1003.
47. Bianchi MT, Macdonald RL. Neurosteroids shift partial agonist activation of GABA(A) receptor channels from low- to high-efficacy gating patterns. J Neurosci. 2003 Nov 26; 23(34):10934-43.
48. Macdonald RL, Bianchi MT, Bianch MT, Feng H. Mutations linked to generalized epilepsy in humans reduce GABA(A) receptor current. Exp Neurol. 2003 Nov; 184 Suppl 1:S58-67.
49. Hinkle DJ, Bianchi MT, Macdonald RL. Modifications of a commercial perfusion system for use in ultrafast solution exchange during patch clamp recording. Biotechniques. 2003 Sep; 35(3):472-4, 476.
50. Bianchi, M.T. and Macdonald, R.L. . Neurosteroid Modulation of delta Subunit-Containing GABA-A Receptor Channels . Neurosteroid Effects in the Central Nervous System (Editor: Sheryl S. Smith). 2003.
51. Macdonald, R.L. and Bianchi, M.T. Gamma-Aminobutyric Acid (GABA). Encyclopedia of the Neurological Sciences. (Ed. Aminoff, M. and Daroff, R.). 2003.
52. Bianchi MT, Macdonald RL. Slow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic function. J Physiol. 2002 Oct 1; 544(Pt 1):3-18.
53. Bianchi MT, Haas KF, Macdonald RL. Alpha1 and alpha6 subunits specify distinct desensitization, deactivation and neurosteroid modulation of GABA(A) receptors containing the delta subunit. Neuropharmacology. 2002 Sep; 43(4):492-502.
54. Buhr A, Bianchi MT, Baur R, Courtet P, Pignay V, Boulenger JP, Gallati S, Hinkle DJ, Macdonald RL, Sigel E. Functional characterization of the new human GABA(A) receptor mutation beta3(R192H). Hum Genet. 2002 Aug; 111(2):154-60.
55. Bianchi MT, Song L, Zhang H, Macdonald RL. Two different mechanisms of disinhibition produced by GABAA receptor mutations linked to epilepsy in humans. J Neurosci. 2002 Jul 1; 22(13):5321-7.
56. Matt T. Bianchi (PhD Thesis in the lab of R.L. Macdonald). GABA-A Receptor Properties That Shape Neuronal Inhibition. 2002.
57. Wohlfarth KM, Bianchi MT, Macdonald RL. Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit. J Neurosci. 2002 Mar 1; 22(5):1541-9.
58. Bianchi MT, Macdonald RL. Agonist Trapping by GABAA Receptor Channels. J Neurosci. 2001 Dec 1; 21(23):9083-91.
59. Bianchi MT, Macdonald RL. Mutation of the 9' leucine in the GABA(A) receptor gamma2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states. Neuropharmacology. 2001 Nov; 41(6):737-44.
60. Bianchi MT, Haas KF, Macdonald RL. Structural determinants of fast desensitization and desensitization-deactivation coupling in GABAa receptors. J Neurosci. 2001 Feb 15; 21(4):1127-36.
61. Neelands TR, Fisher JL, Bianchi M, Macdonald RL. Spontaneous and gamma-aminobutyric acid (GABA)-activated GABA(A) receptor channels formed by epsilon subunit-containing isoforms. Mol Pharmacol. 1999 Jan; 55(1):168-78.
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